A methodology for compartmental model indistinguishability.

Abstract

The problem of constructing all minimal compartmental models that are indistinguishable through input-output knowledge alone from some given model is examined. The main tool in this analysis is a set of geometric properties that can be deduced from input-output knowledge and hence must be equally true in any two indistinguishable models. These properties, together with preservation of the form of the model's transfer function(s), provide an effective means for producing a set of candidate models for indistinguishability.