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Transforming growth factors beta 1 and beta 2 as well as milk growth factor decrease anti-CD3-induced proliferation of human lymphocytes without inhibiting the anti-CD3-mediated increase of [Ca2+]i and the activation of protein kinase C.

M Stoeck·H Sommermeyer·S Miescher·D Cox·S Alkan·M Szamel
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Abstract

Porcine transforming growth factor 1 and 2 (pTGF-beta 1 and -beta 2) and milk growth factor (MGF) at 1 ng/ml significantly inhibited the proliferation of human lymphocytes induced by anti-CD3 antibodies. In contrast, the anti-CD3-mediated increase of intracellular Ca2+ and the activation and translocation of protein kinase C were not affected by the transforming growth factors.

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AnimalsAntigens, Differentiation, T-LymphocyteBiological FactorsCD3 ComplexCalciumEnzyme ActivationHumansProtein Kinase CReceptors, Antigen, T-CellSwineT-LymphocytesTransforming Growth FactorsJournal ArticleResearch Support, Non-U.S. Gov't

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M Stoeck, H Sommermeyer, S Miescher, D Cox, S Alkan, M Szamel. 1989-06-05. Transforming growth factors beta 1 and beta 2 as well as milk growth factor decrease anti-CD3-induced proliferation of human lymphocytes without inhibiting the anti-CD3-mediated increase of [Ca2+]i and the activation of protein kinase C.. https://doi.org/10.1016/0014-5793(89)80643-x

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