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Immunological tolerance: new approaches using transgenic mice.

J F Miller·G Morahan·J Allison
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Abstract

Transgenic technology allows the introduction into the germline of an animal of a known gene coding for a normally foreign antigen, and by means of a specific promoter, the direction of its expression to specific tissues. The antigen is therefore synthesized by the animal as an authentic self molecule, at a particular stage in development, and in a particular site. In this review, J.F.A.P. Miller and colleagues discuss this radically new approach to the investigation of the mechanism of acquired immunological tolerance to self components.

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AnimalsAntigens, Polyomavirus TransformingGene Expression RegulationHistocompatibility AntigensImmune ToleranceImmunoglobulinsIslets of LangerhansLymphocytesMiceMice, TransgenicOrgan SpecificityPromoter Regions, GeneticReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaRecombinant Fusion ProteinsRecombinant ProteinsThymus GlandJournal ArticleResearch Support, Non-U.S. Gov'tReview

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J F Miller, G Morahan, J Allison. 1989. Immunological tolerance: new approaches using transgenic mice.. https://doi.org/10.1016/0167-5699(89)90306-x

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