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PubMed · 2527602

Structure, function and subcellular localization of a human platelet Ca2+-ATPase.

W L Dean
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Abstract

Human platelets contain a Ca2+-ATPase in internal membranes that is essential for Ca2+ homeostasis. This Ca2+ pump has enzymatic properties quite similar to the sarcoplasmic reticulum (SR) Ca2+ pumps. Antibodies against the SR Ca2+ pump crossreact with the human platelet protein. However, the platelet Ca2+-ATPase is approximately 10 kD larger than the SR pumps and exhibits a larger mRNA coding for the protein in a megakaryocyte tumor cell line. In addition, the platelet Ca2+-pump may be localized in specialized internal membrane structures that function in Ca2+ uptake and release. These results suggest that the platelet Ca2+-ATPase may represent a new class of internal membrane Ca2+-pumps.

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AntibodiesBiological Transport, ActiveBlood PlateletsCalciumCalcium-Transporting ATPasesHomeostasisHumansIntracellular MembranesRNA, MessengerSarcoplasmic ReticulumTumor Cells, CulturedJournal ArticleReview

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BibTeXRIS

W L Dean. 1989. Structure, function and subcellular localization of a human platelet Ca2+-ATPase.. https://doi.org/10.1016/0143-4160(89)90055-9

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