Fibronectin in multiple sclerosis lesions.

R A Sobel; M E Mitchell

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PubMed · 2528301

Fibronectin in multiple sclerosis lesions.

R A Sobel·M E Mitchell

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Abstract

Cryostat sections of central nervous system (CNS) tissues of patients with multiple sclerosis (MS) and other CNS diseases were stained with antibodies to fibronectin, a macrophage fibronectin receptor component, fibrin/fibrinogen, and albumin using immunoperoxidase. In active, but not inactive, MS plaques vessel fibronectin was increased (to approximately 57% of Factor VIII+ vessels) over uninvolved MS and normal control white matter (P less than 0.001 for both). Fibronectin was primarily localized to vessel walls and amount of staining correlated with degree of inflammation. Active plaques and necrotic lesions also had extracellular fibronectin and fibrin/ogen. These molecules and the fibronectin receptor were found on macrophages. Albumin was more widely and diffusely distributed in lesions than fibronectin. Thus, in addition to extravasation from damaged vessels, fibronectin may be deposited on or synthesized by endothelial cells and macrophages in the CNS. Fibronectin could facilitate monocyte adhesion to endothelial cell luminal surfaces, promote migration of mononuclear cells, and enhance myelin phagocytosis in MS lesions.

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Antibodies Brain Fibrin Fibrinogen Fibronectins Humans Immunohistochemistry Microcirculation Multiple Sclerosis Receptors, Fibronectin Receptors, Immunologic Serum Albumin Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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R A Sobel, M E Mitchell. 1989. Fibronectin in multiple sclerosis lesions.. https://pubmed.ncbi.nlm.nih.gov/2528301/

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