Chronic progressive multiple sclerosis: changes in phenotype and function of T helper subsets.

M R O'Gorman; T Aziz; J Oger

doi:10.1016/0165-5728(89)90110-0

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Chronic progressive multiple sclerosis: changes in phenotype and function of T helper subsets.

M R O'Gorman·T Aziz·J Oger

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Abstract

We have measured pokeweed mitogen-induced IgG secretion by peripheral blood mononuclear cells obtained from two different groups of progressive multiple sclerosis (MS) patients. MS patients with chronic progressive active disease (CPMS-A) have higher IgG secretion than stable (burnt-out) patients (CPMS-S). We have also measured suppressor cell function and phenotyped the T helper cells of some CPMS-A patients. This group differed from CPMS-S and from controls: they had high IgG secretion, low suppression and their T helper phenotypes showed a high ratio of T helper/inducers over T suppressor/inducers.

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Chronic Disease Humans Immunoglobulin G Multiple Sclerosis Phenotype Pokeweed Mitogens T-Lymphocytes, Helper-Inducer T-Lymphocytes, Regulatory Journal Article Research Support, Non-U.S. Gov't

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M R O'Gorman, T Aziz, J Oger. 1989. Chronic progressive multiple sclerosis: changes in phenotype and function of T helper subsets.. https://doi.org/10.1016/0165-5728(89)90110-0

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