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PubMed · 2532848

P53 and oncogenes expression in psoriasis.

G Tadini·A Cerri·L Crosti·G Cattoretti·E Berti
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Abstract

Activity of p53, H-ras, c-myc and c-fos in psoriatic lesions was studied using monoclonal antibodies (MoAbs) performing a sensitive immunohistochemical method on frozen sections. Normal skin from surgery was used as control. Reactivity of p53, H-ras and c-myc is remarkable in psoriatic plaques but, in contrast, c-fos expression does not show differences compared to control skin. These findings led us to speculate about the importance of cellular oncogenes in the pathogenesis of psoriasis.

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Antibodies, MonoclonalBiopsyCell CycleCell DifferentiationGene ExpressionHumansImmunohistochemistryOncogene ProteinsOncogenesPhosphoproteinsPsoriasisTumor Suppressor Protein p53Journal Article

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G Tadini, A Cerri, L Crosti, G Cattoretti, E Berti. 1989. P53 and oncogenes expression in psoriasis.. https://pubmed.ncbi.nlm.nih.gov/2532848/

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