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Ovariectomy and subchronic estradiol-17 beta administration decrease dopamine D1 and D2 receptors in rat striatum.

J A Tonnaer·T Leinders·A M van Delft
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Abstract

Ovariectomy and subchronic estradiol-17 beta cause a down-regulation of dopamine D1 and, to a lesser extent, D2 receptors in rat striatum. An intracellular mechanism mediates the DA receptor down-regulation, as various estrogens do not interact with membrane-bound DA receptors in vitro. A common denominator, e.g. enhanced DA turnover, is suggested to mediate the estradiol-induced DA receptor down-regulation. Ovarian factors other than estradiol are additionally proposed to be involved in the regulation of striatal DA receptors.

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AnimalsBenzazepinesBinding, CompetitiveCorpus StriatumDopamine AntagonistsEstradiolFemaleOvariectomyPituitary GlandRatsRats, Inbred StrainsReceptors, DopamineReceptors, Dopamine D1Receptors, Dopamine D2SpiperoneJournal Article

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J A Tonnaer, T Leinders, A M van Delft. 1989. Ovariectomy and subchronic estradiol-17 beta administration decrease dopamine D1 and D2 receptors in rat striatum.. https://doi.org/10.1016/0306-4530(89)90046-2

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