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PubMed · 2536900

Designing CD4 immunoadhesins for AIDS therapy.

D J Capon·S M Chamow·J Mordenti·S A Marsters·T Gregory·H Mitsuya·R A Byrn·C Lucas·F M Wurm·J E Groopman
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Abstract

A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic use.

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Acquired Immunodeficiency SyndromeAdjuvants, ImmunologicAnimalsAntigens, SurfaceBinding Sites, AntibodyBinding, CompetitiveCell Adhesion MoleculesCell LineDrug DesignHIV Envelope Protein gp120Half-LifeHumansImmunoglobulin GMiceRabbitsReceptors, ComplementReceptors, FcReceptors, HIVReceptors, VirusRetroviridae ProteinsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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D J Capon, S M Chamow, J Mordenti, S A Marsters, T Gregory, H Mitsuya, R A Byrn, C Lucas, F M Wurm, J E Groopman. 1989-02-09. Designing CD4 immunoadhesins for AIDS therapy.. https://doi.org/10.1038/337525a0

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