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PubMed · 2540615

[Beta receptor blockade and liver function].

J Kulcsár-Gergely
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Abstract

The effects of propranolol on liver functions of healthy rats were studied administering daily doses of 1 mg/kg. Beta receptor blockade has been investigated in carbontetrachloride induced liver cirrhosis. Normal liver functions were unchanged with the exception of an increase in Glucos-6-Phosphatase. The severe cirrhotic injuries were counteracted or moderated when propranolol administration started the same day as CCl4 injection. The amount and function of mixed-function-monooxygenases were normalised. Carbohydrate and protein metabolism impairments were moderated. Serum triglyceride and HDL-cholesterin levels were however uninfluenced. The metabolic properties of propranolol seem to be advantageous in chronic liver impairments.

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AnimalsCarbon Tetrachloride PoisoningLiverMalePropranololRatsRats, Inbred StrainsReceptors, Adrenergic, betaReference ValuesEnglish AbstractJournal Article

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J Kulcsár-Gergely. 1989. [Beta receptor blockade and liver function].. https://pubmed.ncbi.nlm.nih.gov/2540615/

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