How do inositol phosphates regulate calcium signaling?

J W Putney; H Takemura; A R Hughes; D A Horstman; O Thastrup

doi:10.1096/fasebj.3.8.2542110

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PubMed · 2542110

How do inositol phosphates regulate calcium signaling?

J W Putney·H Takemura·A R Hughes·D A Horstman·O Thastrup

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Abstract

Activation of a variety of cell surface receptors results in the phospholipase C-catalyzed hydrolysis of the minor plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate, with concomitant formation of inositol 1,4,5-trisphosphate and diacylglycerol. There is strong evidence that inositol 1,4,5-trisphosphate stimulates Ca2+ release from intracellular stores. The Ca2+-releasing actions of inositol 1,4,5-trisphosphate are terminated by its metabolism through two distinct pathways. Inositol 1,4,5-trisphosphate is dephosphorylated by a 5-phosphatase to inositol 1,4-bisphosphate; alternatively, inositol 1,4,5-trisphosphate can also be phosphorylated to inositol 1,3,4,5-tetrakisphosphate by a 3-kinase. Although the mechanism of Ca2+ mobilization is understood, the precise mechanisms involved in Ca2+ entry are not known; the proposal that inositol 1,4,5-trisphosphate secondarily elicits Ca2+ entry by emptying an intracellular Ca2+ pool is considered.

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Animals Calcium Calcium Channels Cell Membrane Humans Inositol 1,4,5-Trisphosphate Inositol 1,4,5-Trisphosphate Receptors Inositol Phosphates Phosphorylation Receptors, Cell Surface Receptors, Cytoplasmic and Nuclear Signal Transduction Sugar Phosphates Type C Phospholipases Journal Article Review

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J W Putney, H Takemura, A R Hughes, D A Horstman, O Thastrup. 1989. How do inositol phosphates regulate calcium signaling?. https://doi.org/10.1096/fasebj.3.8.2542110

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