Spatial and temporal expression pattern of retinoic acid receptor genes during mouse bone development.

S Noji; T Yamaai; E Koyama; T Nohno; S Taniguchi

doi:10.1016/0014-5793(89)81794-6

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Spatial and temporal expression pattern of retinoic acid receptor genes during mouse bone development.

S Noji·T Yamaai·E Koyama·T Nohno·S Taniguchi

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Abstract

Spatial and temporal expression pattern of retinoic acid receptor (RAR) genes was investigated in mouse finger bones during development by an in situ hybridization method with riboprobes synthesized from a human cDNA of the RAR-alpha. We found that the RAR genes are expressed intensively and specifically in calcifying fronts of the mouse finger bones, whereas the expression pattern is rather uniform in the limb buds and cartilage matrices of the embryonic fingers. Our findings are consistent with the fact that vitamin A is essential for normal mammalian bone development.

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Animals Bone Development Bone and Bones Carrier Proteins DNA Gene Expression Genes Male Mice Mice, Inbred C3H Nucleic Acid Hybridization Osteogenesis RNA, Messenger Receptors, Retinoic Acid Templates, Genetic Transcription, Genetic Tretinoin Journal Article Research Support, Non-U.S. Gov't

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S Noji, T Yamaai, E Koyama, T Nohno, S Taniguchi. 1989-10-23. Spatial and temporal expression pattern of retinoic acid receptor genes during mouse bone development.. https://doi.org/10.1016/0014-5793(89)81794-6

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