Cyclic-AMP in human lung preparations.

B Ali; S S Parmar; E C James

doi:10.1016/0031-9384(89)90332-6

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Cyclic-AMP in human lung preparations.

B Ali·S S Parmar·E C James

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Abstract

Cyclic-AMP levels in unaffected and affected cancerous portions of human lung preparations were determined by measuring displaced 3H-cyclic-AMP from the specific binding protein by unlabeled ligand. The levels of cyclic-AMP in unaffected portions of human lungs ranged between 52-116 pmoles/g protein. Significantly higher levels of cyclic-AMP were found in lung samples affected with squamous cell carcinoma, adenocarcinoma and malignant melanoma with the mean values being 251, 290, and 509 pmoles/g protein, respectively. On the other hand, a decrease in the level of cyclic-AMP to 39 pmoles/g protein was observed in portions of lungs affected with granuloma. These results suggest that the level of cyclic-AMP in lung tissue may reflect the malignant or benign nature of the pulmonary disease.

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Adenocarcinoma Carcinoma, Squamous Cell Carrier Proteins Cyclic AMP Cyclic AMP Receptor Protein Granuloma Humans Lung Lung Diseases Lung Neoplasms Melanoma Journal Article Research Support, Non-U.S. Gov't

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B Ali, S S Parmar, E C James. 1989. Cyclic-AMP in human lung preparations.. https://doi.org/10.1016/0031-9384(89)90332-6

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