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Relationship between pituitary ACTH content and hypothalamic catecholamines in the rat.

H Lehnert·J Beyer·D K Reinstein·U I Richardson·R J Wurtman
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Abstract

Hypothalamic concentrations of epinephrine and norepinephrine were determined in rats following 6-hydroxydopamine lesions of the locus coeruleus and subcoeruleus system and following sham-operation. These concentrations were correlated with pituitary ACTH content. While the lesion procedure did not have a major effect on hypothalamic monoamine levels, we were able to demonstrate a strong negative correlation between hypothalamic epinephrine and pituitary ACTH content independent of the experimental condition. Only a weak negative correlation was observed for hypothalamic norepinephrine and pituitary ACTH. Our recent and previous data suggest a tonic and phasic inhibition of ACTH release by hypothalamic monoamines.

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Adrenocorticotropic HormoneAnimalsEpinephrineHypothalamusMaleNorepinephrinePituitary Gland, AnteriorRatsRats, Inbred StrainsTyrosineComparative StudyJournal Article

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H Lehnert, J Beyer, D K Reinstein, U I Richardson, R J Wurtman. 1989. Relationship between pituitary ACTH content and hypothalamic catecholamines in the rat.. https://doi.org/10.1007/bf01852261

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