Exploring delta-receptor function using the selective opioid antagonist naltrindole.

H C Jackson; T L Ripley; D J Nutt

doi:10.1016/0028-3908(89)90022-1

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Exploring delta-receptor function using the selective opioid antagonist naltrindole.

H C Jackson·T L Ripley·D J Nutt

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Abstract

Until recently the only pharmacological probes for delta-receptors have been peptide enkephalin analogues. These suffer from a number of limitations including high cost, partial agonist effects and a propensity for neurotoxicity. A stable non-peptide antagonist, naltrindole, has recently become available. We have explored its intrinsic actions and found that it attenuated swim stress-induced antinociception, a model for endogenous delta-receptor activation. Naltrindole may therefore be a useful alternative to presently available delta-receptor antagonists.

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Animals Behavior, Animal Indoles Male Morphinans Naltrexone Narcotic Antagonists Pain Rats Rats, Inbred Strains Receptors, Opioid Receptors, Opioid, delta Stress, Psychological Journal Article

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H C Jackson, T L Ripley, D J Nutt. 1989. Exploring delta-receptor function using the selective opioid antagonist naltrindole.. https://doi.org/10.1016/0028-3908(89)90022-1

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