PubMed · 2561028
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W F Hotmes, J D Cunningham, E Alford. 1989. Generic vs. proprietary otic drops.. https://pubmed.ncbi.nlm.nih.gov/2561028/
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Sulfamethoxazole and trimethoprim have been extracted from a drug formulation, Septra Infusion, with pure supercritical carbon dioxide. Both direct extraction of the aqueous-based matrix and indirect extraction of the formulation immobilized onto Celite were studied. Exhaustive analytical extraction was achieved when active components were less than 1.0 mg. A number of co-extractants were found, but each was blind to the HPLC/UV assay.