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PubMed · 2565161

Positive inotropic/vasodilator agents.

W S Colucci
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Abstract

Beta-adrenergic sympathomimetic agents such as dobutamine and dopamine, and phosphodiesterase inhibitors such as amrinone, milrinone, and enoxamone, exert a direct positive inotropic effect upon the myocardium by causing an increase in cyclic AMP levels. The phosphodiesterase inhibitors also exert a substantial direct vasodilator effect. Both the sympathomimetic agents and the phosphodiesterase inhibitors can be of value in the acute, short-term management of myocardial failure. At present, the use of these agents for long-term therapy of congestive heart failure is unproven, and remains investigational.

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Adrenergic beta-AgonistsDrug Therapy, CombinationHeart FailureHumansPhosphodiesterase InhibitorsJournal ArticleReview

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BibTeXRIS

W S Colucci. 1989. Positive inotropic/vasodilator agents.. https://pubmed.ncbi.nlm.nih.gov/2565161/

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