The neu (c-erbB-2) oncogene.

H C Maguire; M I Greene

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PubMed · 2565604

The neu (c-erbB-2) oncogene.

H C Maguire·M I Greene

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Abstract

The neu gene was first identified in rat tumors that had been induced by the carcinogen ethyl nitrosourea. The human homolog of neu, usually designated c-erbB-2, is located on chromosome 17, q21. It specifies a transmembrane receptor-like phosphoglycoprotein that is closely related to the EGFr (c-erbB-1). The ligand for c-erbB-2 is not known. A significant proportion of adenocarcinomas (especially of the breast, colon, and pancreas) have amplification and/or overexpression of c-erbB-2. The unique qualities associated with the subset of tumors that overexpress c-erbB-2 have not yet been firmly identified.

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Adenocarcinoma Animals Antibodies, Monoclonal Breast Neoplasms Chromosome Mapping Chromosomes, Human, Pair 17 Ethylnitrosourea Gene Amplification Humans Mice Neuroblastoma Oncogenes Proto-Oncogene Proteins Rats Erb-b2 Receptor Tyrosine Kinases Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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H C Maguire, M I Greene. 1989. The neu (c-erbB-2) oncogene.. https://pubmed.ncbi.nlm.nih.gov/2565604/

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