Bromocriptine-induced hypothermia: D-2 receptor involvement.

M R Zarrindast; M Mahmoudi

PubMed · 2569299

Bromocriptine-induced hypothermia: D-2 receptor involvement.

Abstract

Bromocriptine (2-16 mg/kg, i.p.) caused a dose-dependent fall in core body temperature of mice. The hypothermic effect of bromocriptine was decreased by pretreatment of the animals with sulpiride, but SCH 23390, methergoline, phenoxybenzamine, propranolol and atropine did not decrease the response. Administration of reserpine plus alpha-methyl-p-tyrosine prior to bromocriptine injection abolished hypothermia in mice. It is concluded that D-2 dopamine receptors may be involved in bromocriptine-induced hypothermia.

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Adrenergic alpha-Antagonists Adrenergic beta-Antagonists Animals Body Temperature Bromocriptine Dopamine Antagonists Injections, Intraperitoneal Male Methyltyrosines Mice Parasympatholytics Receptors, Dopamine Reserpine Serotonin Antagonists alpha-Methyltyrosine Journal Article

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M R Zarrindast, M Mahmoudi. Bromocriptine-induced hypothermia: D-2 receptor involvement.. https://pubmed.ncbi.nlm.nih.gov/2569299/

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