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Antigen processing: current issues, exceptional cases (Thy 1 alloantigen, MHC class-II-restricted cytolytic T cells), and implications for vaccine development.

B M Chain·N A Mitchison·T J Mitchison·D H Davies·J Marcinkiewicz
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Abstract

A dogmatic view of antigen processing is presented in outline, followed by a survey of unresolved issues in the subject. The activity of Thy 1 as an alloantigen, and allospecific MHC Class-II-restricted cytolytic T cells offer examples of exceptional cases of antigen presentation. Implications for the design of vaccines are drawn.

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AnimalsAntigen-Presenting CellsAntigensAntigens, SurfaceBiological Transport, ActiveHistocompatibility Antigens Class IIHumansT-Lymphocytes, CytotoxicThy-1 AntigensVaccinesJournal ArticleReview

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B M Chain, N A Mitchison, T J Mitchison, D H Davies, J Marcinkiewicz. 1989. Antigen processing: current issues, exceptional cases (Thy 1 alloantigen, MHC class-II-restricted cytolytic T cells), and implications for vaccine development.. https://doi.org/10.1016/0896-8411(89)90116-9

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