Ischemic flow threshold for extracellular glutamate increase in cat cortex.

N Shimada; R Graf; G Rosner; A Wakayama; C P George; W D Heiss

doi:10.1038/jcbfm.1989.86

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Ischemic flow threshold for extracellular glutamate increase in cat cortex.

N Shimada·R Graf·G Rosner·A Wakayama·C P George·W D Heiss

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Abstract

Extracellular glutamate (Glu), cerebral blood flow (CBF), and auditory-evoked potentials (AEPs) were measured concurrently using microdialysis and hydrogen clearance in the auditory cortex of anesthetized cats during global ischemia of various severities. A threshold-type relationship was observed between extracellular Glu and CBF: Glu increased at CBF levels below about 20 ml/100 g/min. The Glu increase was related to the impairment of AEPs. The results suggest that Glu neurotoxicity is an important factor for ischemic neuronal injury even in penumbra.

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Animals Brain Ischemia Cats Cerebral Cortex Cerebrovascular Circulation Differential Threshold Evoked Potentials, Auditory Extracellular Space Female Glutamates Glutamic Acid Male Osmolar Concentration Journal Article

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N Shimada, R Graf, G Rosner, A Wakayama, C P George, W D Heiss. 1989. Ischemic flow threshold for extracellular glutamate increase in cat cortex.. https://doi.org/10.1038/jcbfm.1989.86

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