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Bromocriptine-induced decrease in blood pressure in conscious spontaneously hypertensive rats: evidence for a peripheral site of action.

M van den Buuse·A C Lambrechts
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Abstract

The aim of the study was to discover whether the dopamine agonist bromocriptine has a central or peripheral site of action on blood pressure. An intraperitoneal injection of bromocriptine (0.5 mg kg-1) induced a long-lasting decrease in blood pressure in conscious spontaneously hypertensive rats (SHR). This effect was blocked by peripheral pretreatment with haloperidol or domperidone, but not by central treatment with haloperidol. A central injection of bromocriptine had only minor effects on blood pressure. These results suggest that primarily peripheral, rather than central, mechanisms are involved in the hypotensive effects of bromocriptine.

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AnimalsBlood PressureBromocriptineDomperidoneHypertensionInjections, IntraperitonealInjections, IntraventricularMaleRatsRats, Inbred SHRRats, Inbred WKYJournal Article

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BibTeXRIS

M van den Buuse, A C Lambrechts. 1989. Bromocriptine-induced decrease in blood pressure in conscious spontaneously hypertensive rats: evidence for a peripheral site of action.. https://doi.org/10.1111/j.2042-7158.1989.tb06549.x

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