beta-Amyloid precursor is a PEST protein.

R Siman; G Christoph

doi:10.1016/0006-291x(89)92744-7

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beta-Amyloid precursor is a PEST protein.

R Siman·G Christoph

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Abstract

The beta-amyloid peptide is generated by proteolytic processing of a family of beta-amyloid precursor proteins. Here we report that beta-amyloid precursor proteins have a primary structure motif known as a PEST sequence, which is predictive of the class of most protease-sensitive rapidly turning over proteins. Consistent with this, the precursors were extraordinarily susceptible to degradation by the calcium-dependent protease calpain I. The identification of beta-amyloid precursors as PEST sequence-containing proteins has implications for both the normal cellular function of beta-amyloid precursor proteins and the mechanisms regulating their expression and processing.

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Amino Acid Sequence Amyloid Amyloid beta-Protein Precursor Animals Aspartic Acid Brain Chemistry Calpain Glutamates Glutamic Acid Molecular Sequence Data Proline Protease Inhibitors Protein Precursors Rats Serine Threonine Journal Article

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R Siman, G Christoph. 1989-12-29. beta-Amyloid precursor is a PEST protein.. https://doi.org/10.1016/0006-291x(89)92744-7

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