Benzodiazepines decrease the release of [3H]noradrenaline and of [3H]acetylcholine in the cat superior cervical ganglion.

E J Filinger; A B Elgoyhen; E Adler-Graschinsky

doi:10.1016/0304-3940(89)90036-0

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Benzodiazepines decrease the release of [3H]noradrenaline and of [3H]acetylcholine in the cat superior cervical ganglion.

E J Filinger·A B Elgoyhen·E Adler-Graschinsky

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Abstract

The effects of two benzodiazepines, diazepam and clonazepam, were studied on the release of [3H]noradrenaline and of [3H]acetylcholine elicited by preganglionic stimulation of the cat isolated superior cervical ganglion and on the contractile responses evoked by either nerve stimulation or exogenous noradrenaline in the cat isolated nictitating membrane. Both 10 microM diazepam and 10 microM clonazepam reduced by approximately 50% the release of [3H]noradrenaline and of [3H]acetylcholine in the cat ganglion whereas they did not modify the contractile responses in the nictitating membrane. It is concluded that benzodiazepines are also peripheral neuroactive agents and that they exhibit a tissue-selective action within the same animal species.

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Acetylcholine Animals Anti-Anxiety Agents Cats Clonazepam Diazepam Electric Stimulation Ganglia, Sympathetic Neurons Nictitating Membrane Norepinephrine Journal Article Research Support, Non-U.S. Gov't

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E J Filinger, A B Elgoyhen, E Adler-Graschinsky. 1989-10-23. Benzodiazepines decrease the release of [3H]noradrenaline and of [3H]acetylcholine in the cat superior cervical ganglion.. https://doi.org/10.1016/0304-3940(89)90036-0

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