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CD2 expression in murine B cell lineage.

H Yagita·T Nakamura·J Asakawa·H Matsuda·S Tansyo·Y Iigo·K Okumura
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Abstract

CD2 expression in murine B cell lineage was examined by flow cytometric and immunoprecipitation studies with anti-murine CD2 mAb and by Northern blot analysis. Cell surface expression of CD2 was demonstrated on all peripheral B cells and cell lines of B lineage. The murine CD2 transcript of 1.3 kb was detected in these B cells. An identical glycoprotein of 55-67 KD was precipitated from the lysates of surface radioiodinated thymocytes, splenic T and B cells, T and B lymphomas, RL male 1 and BCL-1, with anti-murine CD2 mAb. The majority of bone marrow B cells and a half of pre-B cells were found to be positive for CD2 expression. These results indicate that murine CD2 is expressed on B cell lineage at certain differentiation stages.

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AnimalsAntibodies, MonoclonalAntigens, Differentiation, T-LymphocyteB-LymphocytesCD2 AntigensCell DifferentiationCell LineHematopoietic Stem CellsMiceReceptors, ImmunologicJournal ArticleResearch Support, Non-U.S. Gov't

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H Yagita, T Nakamura, J Asakawa, H Matsuda, S Tansyo, Y Iigo, K Okumura. 1989. CD2 expression in murine B cell lineage.. https://doi.org/10.1093/intimm%2F1.1.94

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