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PubMed · 2585700

[Impaired B lymphocyte function during open heart surgery].

K Hirai·T Shimomura·S Ishizaka·M Shimokawa·K Kitaguchi·N Yamagishi·M Kuro·T Okuda
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Abstract

Sequential in vitro lymphocyte function tests in 13 patients undergoing cardiac operation were performed to study B lymphocyte function following operation. Lymphocytes were stimulated with phytohemagglutinin (PHA), pokeweed mitogen (PWM) and Staphylococcus aureus Cowan 1 (SAC). Mitogen responses were measured by 3H-labeled thymidine incorporation. The SAC responses were significantly depressed following operation. Immunoglobulin secreting cells were measured by protein A plaque forming cell assay. The numbers of immunoglobulin secreting cells induced by PWM or SAC decreased remarkably at least as long as 3 day after the operation. The percentage of circulating B lymphocytes increased significantly postoperatively. This indicates that the B lymphocytes remaining after the operation were functionally impaired.

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Antibody-Producing CellsB-LymphocytesCardiac Surgical ProceduresFemaleHumansLeukocyte CountLymphocyte ActivationMaleMiddle AgedEnglish AbstractJournal Article

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K Hirai, T Shimomura, S Ishizaka, M Shimokawa, K Kitaguchi, N Yamagishi, M Kuro, T Okuda. 1989. [Impaired B lymphocyte function during open heart surgery].. https://pubmed.ncbi.nlm.nih.gov/2585700/

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