PubMed · 2600350
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
P A Greenberger. 1989. Nasal provocation and pulmonary function tests.. https://doi.org/10.1016/0091-6749(89)90166-8
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
The long-term pulmonary consequences of right middle lobe syndrome (RMLS) in childhood are not known. Therefore, outcome was evaluated in 17 children with RMLS diagnosed in early childhood (mean age, 3.3 years; SD, 1.1 year). Mean age at follow-up was 10.1 years (SD, 2.6 years). RMLS was defined as atelectasis of the right middle lobe (RML) of at least 1 month's duration and visible on the lateral view of the chest radiograph as a wedge-shaped density extending from the hilum anteriorly and downward. Seventeen children without personal history of allergy or respiratory tract disease were studied as control group. Five of 17 study group children had ongoing respiratory problems: symptoms of asthma were present in 4 patients, and cylindrical bronchiectasis was present in one patient. Chest radiograph at follow-up was abnormal in six patients. Pulmonary function tests, including mean and SEM for vital capacity (VC) (82% of predicted +/- 7 vs 94% predicted +/- 3), FEV1 (77% of predicted +/- 12 vs 96% of predicted +/- 4) and their ratio (75 +/- 5 vs 85 +/- 3) were significantly lower in patients with ongoing respiratory symptoms than in the control children. The provocative dose causing a 20% decrease in FEV1 (PD20) of methacholine was significantly lower in patients with ongoing symptoms at follow-up than in control children and in patients without symptoms at follow-up (2.8[2.2 to 3.1] vs 4.5[2.2 to 8.8] and 9.2[2.3 to 24] mg/mL; median and P25-75, p < 0.05). Age at initial diagnosis tended to be younger in patients with ongoing symptoms at follow-up (2.3 +/- 0.7 years vs 3.8 +/- 0.4 years; p < 0.08).
Explore the source record for details and available documents.
Research on occupational lung disease has been a growing challenge over the past 4 decades. Exposure to respiratory toxins has increased in many industrializing countries of the world while new and old hazards continue to exist in the industrialized world. The focus of this paper is on measurement tools commonly used in the study of occupational lung diseases. The emphasis is on epidemiology, a discipline which has contributed to the understanding and control of occupational lung disease. An examination of these tools reveals that (1) there are more commonalities than contrasts in available methods; (2) researchers in industrializing settings can contribute much to our understanding of occupational lung diseases; (3) international collaboration is needed in refining measurement tools; and (4) international collaboration should proceed on studies of preventive strategies.