Solid-phase synthesis of oligoribonucleotides.

Y Z Xu; C Lehmann; G Slim; C Christodoulou; Z K Tan; M J Gait

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PubMed · 2608470

Solid-phase synthesis of oligoribonucleotides.

Y Z Xu·C Lehmann·G Slim·C Christodoulou·Z K Tan·M J Gait

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Abstract

An efficient method is described for solid-phase synthesis of oligoribonucleotides that involves use of the 9-fluorenylmethoxycarbonyl group (Fmoc) for 5'-protection, 4-methoxytetrahydropyran-4-yl (Mthp) for 2'-protection and a phosphoramidite coupling procedure.

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Y Z Xu, C Lehmann, G Slim, C Christodoulou, Z K Tan, M J Gait. 1989. Solid-phase synthesis of oligoribonucleotides.. https://pubmed.ncbi.nlm.nih.gov/2608470/

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