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PubMed · 2609138

[Probenecid affects liver metabolism].

A Bammel·H Mönig·K H Zurborn·E E Ohnhaus·W Kirch
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Abstract

The effect of probenecid on the pharmacokinetics of phenprocoumon (PPC) given as a single oral or intravenous dose, on the vitamin-K-dependent protein-C-antigen, and on the pharmacokinetics of antipyrine and 6 beta-hydroxycortisol was determined in 14 healthy volunteers. Probenecid caused a 75% decrease in urinary excretion of PPC and PPC-glucuronide and shortened the plasma half-life of PPC significantly (by about 35%). The results after oral and intravenous administration of PPC did not differ significantly. Plasma protein-C-antigen concentrations following intravenous PPC were significantly increased by probenecid. The plasma half-life of antipyrine after 7 days of probenecid therapy was significantly diminished. Accordingly, urinary excretion of 6 beta-hydroxycortisol was significantly increased. These data appear for the first time to reveal enzyme-inducing properties of probenecid, which may be responsible for the shortening of PPC plasma half-life when probenecid is given simultaneously. In addition, the influence of probenecid on plasma protein-C-antigen concentrations may indicate further effects of probenecid on liver metabolism.

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4-HydroxycoumarinsAdultAntigensAntipyrineHumansHydrocortisoneLiverPhenprocoumonProbenecidProtein CClinical TrialEnglish AbstractJournal ArticleRandomized Controlled Trial

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A Bammel, H Mönig, K H Zurborn, E E Ohnhaus, W Kirch. 1989-12-16. [Probenecid affects liver metabolism].. https://pubmed.ncbi.nlm.nih.gov/2609138/

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