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Fibronectin in reproduction.

T T Hung·A Tsuiki·M Yemini
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Abstract

The fibronectin (FN) levels in human follicular fluids have been shown to correlate well with follicular size and oocyte maturity, suggesting a role of FN in oocyte maturation. When added to the culture medium, the synthetic peptide Gly-Arg-Gly-Asp-Ser (GRGDS), which specifically inhibits the cell-binding of FN, has been shown to inhibit both spontaneous resumption of meiosis and gonadotropin-releasing hormone-induced meiosis of the oocytes. In another set of experiments, GRGDS has been found to inhibit the in vitro cleavage of mouse embryos by a still unknown mechanism.

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AnimalsEmbryonic and Fetal DevelopmentFemaleFibronectinsFollicular FluidHumansIn Vitro TechniquesMiceOocytesOvarian FollicleReproductionJournal Article

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T T Hung, A Tsuiki, M Yemini. 1989. Fibronectin in reproduction.. https://doi.org/10.1016/0039-128x(89)90081-0

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