Nitrile-induced behavioral abnormalities in mice.

H Tanii; M Hayashi; K Hashimoto

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PubMed · 2616059

Nitrile-induced behavioral abnormalities in mice.

H Tanii·M Hayashi·K Hashimoto

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Abstract

A single oral dose of crotononitrile or 2-pentenenitrile induced behavioral abnormalities such as circling, hyperactivity and head twitching. Crotononitrile induced the abnormalities in both olive oil- and CCl4 pretreated mice, whereas 2-pentenenitrile induced the abnormalities only in CCl4-pretreated mice. Seven related compounds induced no behavioral abnormality. The head twitching by crotononitrile and 2-pentenenitrile was either reduced by treatment with serotonin and dopamine antagonists, or enhanced by a serotonin releaser, suggesting that both the serotonin and dopamine systems are involved in the behavioral abnormalities induced by these two nitriles.

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Animals Behavior, Animal Carbon Tetrachloride Dopamine Drug Interactions Male Mice Mice, Inbred Strains Nitriles Psychotropic Drugs Serotonin Journal Article

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H Tanii, M Hayashi, K Hashimoto. 1989. Nitrile-induced behavioral abnormalities in mice.. https://pubmed.ncbi.nlm.nih.gov/2616059/

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