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Evidence for the interaction of urapidil with 5-HT1A receptors in the brain leading to a decrease in blood pressure.

N Kolassa·K D Beller·K H Sanders
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Abstract

Current knowledge about the role of serotonin (5-HT) in central cardiovascular regulation is reviewed. Results from experiments with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) suggest that activation of somatodendritic 5-HT1A receptors in the medulla oblongata decreases the firing of serotoninergic neurons and thus reduces their excitatory input to the sympathetic neurons in the intermediolateral cell column. As a consequence, blood pressure is reduced by 5-HT1A receptor agonists. Urapidil is an antihypertensive drug that has a dual mode of action: peripheral alpha-adrenoceptor antagonism and interaction with 5-HT1A receptors in the brain. This profile can adequately explain the vasodilation and lack of significant sympathetic activation observed during urapidil treatment.

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AnimalsBlood PressureCardiovascular SystemHumansMedulla OblongataPiperazinesReceptors, SerotoninVasodilationJournal ArticleReview

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N Kolassa, K D Beller, K H Sanders. 1989-02-02. Evidence for the interaction of urapidil with 5-HT1A receptors in the brain leading to a decrease in blood pressure.. https://doi.org/10.1016/0002-9149(89)90404-9

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