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Risk factors for halothane hepatitis.

M J Cousins·J L Plummer·P D Hall
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Abstract

Helothane hepatitis is a rare but sometimes fatal complication of halothane anaesthesia. Examination of case reports has pointed to a number of risk factors. Studies in animals and humans in the laboratory have provided evidence of a complex multifactorial basis for halothane hepatotoxicity, with the following factors playing a part: genetic predisposition; metabolism of halothane; repeated halothane anaesthetics; female sex; age of patient; intrahepatic hypoxia; and enzyme induction. Immunologic changes can be detected in a high percentage of cases of halothane hepatitis; however, studies establishing a cause-effect relationship are not available to determine if these changes cause, or result from, hepatic damage.

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AnesthesiaAnimalsChemical and Drug Induced Liver InjuryHalothaneHumansLiverRisk FactorsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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BibTeXRIS

M J Cousins, J L Plummer, P D Hall. 1989. Risk factors for halothane hepatitis.. https://doi.org/10.1111/j.1445-2197.1989.tb01457.x

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