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Simultaneous evaluation of insulin secretion and action using a model.

Y Yamasaki·R Kawamori·R Tohdo·M Nomura·M Kubota·T Kamada·M Shichiri
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Abstract

For the simultaneous evaluation of insulin secretion and insulin sensitivity, a glucose regulation model has been developed. In order to estimate the parameters of the model, an intravenous glucose infusion test (GIT, 100 mg/kg.min x 2 min and 10 mg/kg.min x 118 min) was carried out on 15 healthy subjects (N), 12 subjects with impaired glucose tolerance (IGT), 20 non-insulin-dependent diabetics (NIDDM) and 13 patients with chronic pancreatitis (CP). The coefficient (microU/mg) for insulin secretion depending on blood glucose concentration in IGT, NIDDM and CP were lower (35.9 +/- 2.7, 24.5 +/- 3.3, 43.1 +/- 3.1) than in N (77.5 +/- 7.9). The coefficients (microU.min/mg) for insulin secretion depending on rate of change in blood glucose concentration in IGT and NIDDM were significantly lower (6.5 +/- 2.1, 3.8 +/- 1.2) than in N (52.8 +/- 8.8). The insulin sensitivity index (ISI; 10(-2) mg/(microU/ml).kg.min) in NIDDM was lower (4.98 +/- 0.75) than in N (11.37 +/- 1.08). Administration of exogenous insulin did not significantly affect the value of ISI in N and NIDDM. ISI showed a tendency to increase (15.09 +/- 1.92) in CP. It was demonstrated that the proposed model which estimates both insulin secretory ability and insulin sensitivity simultaneously is quite useful for analyzing the mechanism of impaired glucose tolerance.

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AdultBlood GlucoseChronic DiseaseDiabetes Mellitus, Type 2Glucose Tolerance TestHumansHyperglycemiaInsulinInsulin SecretionKineticsMathematicsMiddle AgedModels, TheoreticalPancreatitisReference ValuesComparative StudyJournal Article

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BibTeXRIS

Y Yamasaki, R Kawamori, R Tohdo, M Nomura, M Kubota, T Kamada, M Shichiri. 1989-01-03. Simultaneous evaluation of insulin secretion and action using a model.. https://doi.org/10.1016/0168-8227(89)90053-3

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