Platelet activating factor in pulmonary pathobiology.

L M McManus; S I Deavers

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PubMed · 2650961

Platelet activating factor in pulmonary pathobiology.

L M McManus·S I Deavers

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Abstract

Platelet activating factor (PAF) is a potent phospholipid mediator of inflammation that has been gaining increasing attention because of its pathophysiologic effects upon the lung. In particular, PAF stimulates pulmonary hypertension, ventilatory alterations, bronchoconstriction, airway hyperreactivity, and pulmonary inflammatory cell accumulation and edema in a variety of experimental animals and in humans. These observations promote the speculation that this unique phospholipid likely is involved in similar tissue responses during the course of human lung disease. The use of specific PAF antagonists should expand our understanding of these processes and may be useful in treating or preventing PAF-mediated pulmonary disorders in the future.

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Animals Blood Platelets Humans Lung Lung Diseases Platelet Activating Factor Journal Article Research Support, U.S. Gov't, P.H.S.Review

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L M McManus, S I Deavers. 1989. Platelet activating factor in pulmonary pathobiology.. https://pubmed.ncbi.nlm.nih.gov/2650961/

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