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The complete islet amyloid polypeptide precursor is encoded by two exons.

S Mosselman·J W Höppener·C J Lips·H S Jansz
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Abstract

Islet amyloid polypeptide (IAPP) is the 37-amino acid peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. Recently, we isolated the human gene encoding IAPP [(1988) FEBS Lett. 239, 227-232]. We now report the nucleotide sequences of a human insulinoma cDNA encoding a complete IAPP precursor, and of the corresponding parts of the IAPP gene. Two exons, which are approx. 5 kb apart in the human genome, encode the 89-amino acid pre-pro-IAPP. At least one additional exon is present further upstream in the IAPP gene. A putative signal sequence at the amino-terminus of the precursor suggests that IAPP is a secreted protein.

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Amino Acid SequenceAmyloidBase SequenceCalcitoninCalcitonin Gene-Related PeptideCodonDNADNA ProbesExonsHumansInsulinomaIslet Amyloid PolypeptideIslets of LangerhansMolecular Sequence DataNeuropeptidesNucleic Acid HybridizationPancreatic NeoplasmsProtein PrecursorsProtein Sorting SignalsSequence Homology, Nucleic AcidComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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S Mosselman, J W Höppener, C J Lips, H S Jansz. 1989-04-10. The complete islet amyloid polypeptide precursor is encoded by two exons.. https://doi.org/10.1016/0014-5793(89)81260-8

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