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'Nuclear' oncogenes convert extracellular stimuli into changes in the genetic program.

P Herrlich·H Ponta
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Abstract

Recent discoveries have advanced our understanding of oncogene action: transcription factors are encoded by cellular (nuclear) oncogenes and the activity of transcription factors is modulated in response to extracellular stimuli. Moreover, the nuclear oncoproteins appear to represent the gene-proximal ends of a network of cellular oncoproteins that link extracellular stimuli to the transcriptional machinery and thus to the program of genes a cell will express.

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Gene Expression RegulationNuclear ProteinsOncogenesPhenotypeSignal TransductionTranscription FactorsJournal ArticleReview

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P Herrlich, H Ponta. 1989. 'Nuclear' oncogenes convert extracellular stimuli into changes in the genetic program.. https://doi.org/10.1016/0168-9525(89)90041-3

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