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PubMed · 2668139

[Long-term therapy with nitrates. How can continuous effectiveness be achieved?].

W Rudolph·J Dirschinger·G Reiniger·A Beyerle
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Abstract

Due to rapidly occurring tolerance, "continuous" administration of nitrates can no longer be considered justified. The development of tolerance can be avoided and, thus, the antiischemic effect maintained during long-term treatment only by providing a nitrate-free interval. Dosing regimens with documented effectiveness in long-term controlled studies are available for both isosorbide dinitrate and isosorbide 5-mononitrate as well as for transdermal nitroglycerin systems.

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Administration, CutaneousAngina PectorisCoronary DiseaseDelayed-Action PreparationsDrug Administration ScheduleHumansIsosorbide DinitrateNitratesJournal ArticleReview

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W Rudolph, J Dirschinger, G Reiniger, A Beyerle. 1989-06-30. [Long-term therapy with nitrates. How can continuous effectiveness be achieved?].. https://pubmed.ncbi.nlm.nih.gov/2668139/

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