Metoprolol-controlled release, zero order kinetics.

M J Kendall

doi:10.1111/j.1365-2710.1989.tb00235.x

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Metoprolol-controlled release, zero order kinetics.

M J Kendall

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Abstract

Metoprolol CR/ZOK (controlled release, zero order kinetics) is a new formulation of an extensively used beta 1-selective, beta-adrenoceptor blocking drug, (beta 1-blocker), designed to provide continuous, even, plasma concentrations in the therapeutic range. It should, therefore, provide an effective well-tolerated treatment for hypertension and angina pectoris and for use in secondary prevention following a myocardial infarct. The purpose of this review is to consider the need for such a formulation, to describe its pharmaceutical development, review its pharmacology and assess its efficacy and tolerability compared with other available agents.

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M J Kendall. 1989. Metoprolol-controlled release, zero order kinetics.. https://doi.org/10.1111/j.1365-2710.1989.tb00235.x

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