Additional Watson-Crick interactions suggest a structural core in large subunit ribosomal RNA.

T Haselman; R R Gutell; J Jurka; G E Fox

doi:10.1080/07391102.1989.10507759

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Additional Watson-Crick interactions suggest a structural core in large subunit ribosomal RNA.

T Haselman·R R Gutell·J Jurka·G E Fox

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Abstract

Two new Watson-Crick type interactions in 23S-like ribosomal RNA have been identified by comparative sequence analysis. These interactions, A1269/U2011 and C1270/G2010 (E. coli numbering) along with the previously proposed A1262/U2017 suggest an anti-parallel helical arrangement characteristic of secondary structure in the 1265/2015 region of 23S rRNA. Nested within these three interactions are three universal juxtapositions which in principle allow the formation of an irregular helix containing two additional A-G interactions and a universal A-U pair. Whether or not this extended helix is biologically significant is uncertain. The proponderance of interactions in the 1265/2015 region and its location relative to the known structural domains of 23S rRNA suggest that this region may be part of a central structural core similar to that already known in 16S rRNA.

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Animals Base Composition Escherichia coli Models, Molecular Nucleic Acid Conformation RNA, Ribosomal RNA, Ribosomal, 16S RNA, Ribosomal, 23S Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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T Haselman, R R Gutell, J Jurka, G E Fox. 1989. Additional Watson-Crick interactions suggest a structural core in large subunit ribosomal RNA.. https://doi.org/10.1080/07391102.1989.10507759

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