Bone metastasis as a non-stochastic process.

M Chigira; K Noda; H Watanabe

doi:10.1016/0306-9877(89)90112-6

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Bone metastasis as a non-stochastic process.

M Chigira·K Noda·H Watanabe

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Abstract

Bone metastasis may be considered a non-stochastic process, since the blood flow in bone is lower than that in other organs and most cancers do not have a tendency to metastasize to bone in in vivo experiments. Furthermore, the experimental model of bone metastasis, based on the ligation of major venous flow, can not explain the wide-spread bone metastasis which is commonly observed in clinical cases. These observations may be explained by the hypothesis that tumor cells have a phenotype for translocating to specific tissues and that tumor cell growth is controlled by the microenvironmental factors in situ.

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Animals Blood Circulation Bone Neoplasms Disease Models, Animal Neoplasm Metastasis Journal Article Research Support, Non-U.S. Gov't

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M Chigira, K Noda, H Watanabe. 1989. Bone metastasis as a non-stochastic process.. https://doi.org/10.1016/0306-9877(89)90112-6

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