Retinoids and vertebrate limb pattern formation.

G Eichele

doi:10.1016/0168-9525(89)90096-6

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Retinoids and vertebrate limb pattern formation.

G Eichele

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Abstract

It has long been suggested that pattern formation depends in part on signalling molecules known as 'morphogens', diffusible substances that determine cell fate in a concentration-dependent way. Retinoic acid, a small hydrophobic molecule that binds to nuclear receptors, is a candidate morphogen for specifying the anteroposterior pattern of vertebrate limbs.

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Animals Chick Embryo Extremities Gene Expression Morphogenesis Signal Transduction Tretinoin Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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G Eichele. 1989. Retinoids and vertebrate limb pattern formation.. https://doi.org/10.1016/0168-9525(89)90096-6

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