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Structure-activity relationships among mycotoxins.

V Betina
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Abstract

Relationships between structural features and biological effects of mycotoxins are reviewed. Structure-activity relationships are characterized at the molecular, subcellular, cellular, or supracellular level. Major chemical and physicochemical factors responsible for bioactivity of mycotoxins are stressed. A variety of chemical families of mycotoxins are then discussed from the point of view of structure-activity relationships. The structurally related families comprise small lactones, macrocyclic lactones, isocoumarin derivatives, aflatoxins and related compounds trichothecenes, anthraquinones, indole-derived tremorgens and selected amino acid-derived mycotoxins such as sporidesmins and cyclosporines. Biological effects of mycotoxins include acute and chronic toxicity, antimicrobial activity, mutagenicity and genotoxicity, carcinogenicity and biochemical modes of action.

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AnimalsCarcinogensMutagensMycotoxinsStructure-Activity RelationshipTeratogensJournal ArticleReview

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V Betina. 1989. Structure-activity relationships among mycotoxins.. https://doi.org/10.1016/0009-2797(89)90030-6

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