Haem as a multifunctional regulator.

G Padmanaban; V Venkateswar; P N Rangarajan

doi:10.1016/0968-0004(89)90182-5

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Haem as a multifunctional regulator.

G Padmanaban·V Venkateswar·P N Rangarajan

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Abstract

Haem has long been known as the prosthetic group of haemoproteins such as haemoglobin, catalase and the cytochromes. Its biosynthesis is regulated by feedback mechanisms that ensure its adequate production but prevent its overaccumulation, which is highly deleterious as diseases such as porphyrias attest. However, recent years have seen rapid strides in our understanding of how haem (or more accurately haemin, its oxidized form) itself acts as an intracellular regulator of a variety of other metabolic pathways for systems that utilize oxygen.

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Animals Biological Transport Gene Expression Regulation Heme Protein Biosynthesis Transcription, Genetic Journal Article Research Support, Non-U.S. Gov't Review

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G Padmanaban, V Venkateswar, P N Rangarajan. 1989. Haem as a multifunctional regulator.. https://doi.org/10.1016/0968-0004(89)90182-5

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