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Dendritic cell ontogeny.

W E Bowers·E M Goodell
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Abstract

Abundant evidence indicates that dendritic cells arise from the bone marrow. In vitro, precursors that differ phenotypically from mature dendritic cells divide several times to form functional dendritic cells. A soluble factor(s) produced in the supernatants of ConA-stimulated spleen cells enhances the production of dendritic cells. This factor(s) has not been fully characterized. Further maturation of dendritic cells occurs after they are released from the bone marrow; species differences exist. Interrelationships between various types of dendritic cells need to be elucidated.

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W E Bowers, E M Goodell. Dendritic cell ontogeny.. https://doi.org/10.1016/0923-2494(89)90047-3

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