New technologies for large-genome sequencing.

W J Martin

doi:10.1139/g89-184

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PubMed · 2698825

New technologies for large-genome sequencing.

W J Martin

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Abstract

Interest in DNA sequencing has increased in recent years and research into new instrument systems to optimize and automate the process has been intensified. A number of commercial devices, from Europe, Japan, and the United States, which instrument aspects of (mainly) the Sanger method, are now available and several new DNA sequencing techniques have been reported. This review briefly describes current methods of DNA sequencing and provides an account of systems presently available or under development for instrumenting the technology. The problems of automation for large-scale DNA sequencing are discussed.

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Automation Autoradiography Bacteriological Techniques Base Sequence Electrophoresis, Polyacrylamide Gel Europe Fluorescent Dyes Gene Amplification International Cooperation Japan Nucleotide Mapping Polymerase Chain Reaction United States Journal Article Research Support, Non-U.S. Gov't Review

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W J Martin. 1989. New technologies for large-genome sequencing.. https://doi.org/10.1139/g89-184

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