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PubMed · 2700773

Pharmacologic provocation and dexamethasone suppression test sensitivity.

C M Swartz·K Breen·V S Wahby
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Abstract

In expectation of improving sensitivity, the standard 1-mg dexamethasone suppression test (DST) was given to 10 depressed inpatients and repeated with theophylline or caffeine and again following 3 days of lorazepam with abrupt discontinuation. Two patients showed nonsuppression on the standard DST; 2 suppressors changed to nonsuppression after lorazepam discontinuation, and 1 also changed after theophylline. This increase from 20 to 40% sensitivity remains significantly less than a desirable minimum 80% sensitivity (p less than 0.001), which suggests that a consistent DST sensitivity of 80% in melancholia is unlikely to be attained.

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CaffeineDepressive DisorderDexamethasoneElectroconvulsive TherapyHumansHydrocortisoneLorazepamPrognosisRandomized Controlled Trials as TopicTheophyllineClinical TrialJournal ArticleRandomized Controlled Trial

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C M Swartz, K Breen, V S Wahby. 1989. Pharmacologic provocation and dexamethasone suppression test sensitivity.. https://doi.org/10.1159/000118585

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