A brain-specific transcription activator.

M Korner; A Rattner; F Mauxion; R Sen; Y Citri

doi:10.1016/0896-6273(89)90266-3

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PubMed · 2701844

A brain-specific transcription activator.

M Korner·A Rattner·F Mauxion·R Sen·Y Citri

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Abstract

We have identified a DNA binding protein, named BETA, that interacts with the same (B) transcriptional regulatory sequence as the known transcription factor NF-kappa B. BETA is found only in gray matter throughout the brain, and not in a variety of other rat tissues. Two binding sites for BETA are present adjacent to the promoter of the rat proenkephalin gene. Transfection of primary brain cultures that express BETA, with a reporter gene driven by the SV40 promoter linked to BETA DNA binding sites, results in transcriptional activation. We infer that BETA is a brain-specific transcription activator.

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Animals Base Sequence Binding Sites Brain DNA-Binding Proteins Electrophoresis Enkephalins NF-kappa B Neurons Promoter Regions, Genetic Protein Precursors Rats Tissue Distribution Transcription Factors Transcription, Genetic Journal Article Research Support, Non-U.S. Gov't

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M Korner, A Rattner, F Mauxion, R Sen, Y Citri. 1989. A brain-specific transcription activator.. https://doi.org/10.1016/0896-6273(89)90266-3

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