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Calcium channel modulators: effects on gastric function.

G B Glavin
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Abstract

Calcium is important in stimulus-secretion coupling in the gut. We therefore examined a dihydropyridine (nitrendipine), a phenylalkylamine (verapamil) and a benzothiazepine (diltiazem) calcium channel blocker as well as a calcium channel 'agonist', CGP 28392, in several models of gastric function. Nitrendipine significantly decreased stress-induced gastric lesions, but was far less efficacious against 100% ethanol-induced lesions. The anti-ulcer effects of nitrendipine were not reversible with indomethacin, sodium meclofenamate or N-ethylmaleimide. Nitrendipine also significantly reduced basal gastric acid output. Verapamil significantly reduced stress lesions in an indomethacin and meclofenamate-reversible manner, but worsened ethanol ulcers. Verapamil also decreased basal acid secretion. Diltiazem decreased stress lesions (indomethacin- and meclofenamate-reversible), worsened ethanol lesions and slightly reduced acid secretion. CGP 28392 exerted a modest stress gastroprotective effect, decreased ethanol lesions and reduced slightly basal acid secretion. A possible clinical role for gastric calcium channel blockade is raised by these results.

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AnimalsCalcium Channel AgonistsCalcium Channel BlockersCold TemperatureEthanolGastric AcidMaleRatsRats, Inbred StrainsRestraint, PhysicalStomachStomach UlcerJournal ArticleResearch Support, Non-U.S. Gov't

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G B Glavin. 1989-02-07. Calcium channel modulators: effects on gastric function.. https://doi.org/10.1016/0014-2999(89)90087-3

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