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PubMed · 2714850

Cells carrying C5b-9 complement complexes in human atherosclerotic wall.

H G Rus·F Niculescu·D Poruţiu·V Ghiurca·R Vlaicu
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Abstract

Fibrous plaques and intimal thickenings of 5 femoral and 5 iliac human arteries obtained at surgery were processed for indirect and double-labeling immunoelectron microscopy using an affinity purified rabbit IgG anti-C5b-9 neoantigen and the EBM 11 monoclonal antibody anti-human macrophages. The C5b-9 complexes were localized in intact cells, disintegrated cells and cell debris enmeshed in the connective tissue matrix. Some of the cell debris bearing C5b-9 deposits was found to be of macrophage origin. Endocyted or exocyted pieces of membrane with pore-forming C5b-9 complexes were also identified. Damage of cells by complement in atherosclerotic lesions may contribute to atherogenesis.

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Antibodies, MonoclonalArteriosclerosisComplement Membrane Attack ComplexComplement System ProteinsFemoral ArteryHumansIliac ArteryMacrophagesJournal Article

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H G Rus, F Niculescu, D Poruţiu, V Ghiurca, R Vlaicu. 1989. Cells carrying C5b-9 complement complexes in human atherosclerotic wall.. https://doi.org/10.1016/0165-2478(89)90039-4

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